Thermo Fisher Scientific RC3H1 Polyclonal Antibody
RC3H1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot에 사용 가능하며, 인간에 반응. 고순도 항원 친화 크로마토그래피로 정제됨. PBS와 20% 글리세롤 용액 형태로 제공되며, 장기 보관 시 -20°C 권장.
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Thermo Fisher Scientific RC3H1 Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the C-terminus region of human RC3H1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792738 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (91%).
- Positive Control: 293T, A431, HeLa, HepG2, 3xFlag-human RC3H1 transfected 293T.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The ring finger protein RC3H1 (Roquin) is a highly conserved member of the RING-type ubiquitin ligase protein family. The M199R mutation leads to excessive production of follicular helper T cells and germinal centers in the sanroque strain of mice, resulting in high titers of autoantibodies. Complete loss of RC3H1 induces early death and immune deregulation but not autoimmunity, suggesting that the mutant RC3H1 is more disruptive to the immune system than its complete loss.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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