Thermo Fisher Scientific Endostatin Polyclonal Antibody
Thermo Fisher Scientific의 Endostatin Polyclonal Antibody는 인간 및 마우스 단백질에 반응하는 rabbit polyclonal 항체입니다. Western blot, IHC(P), ICC/IF에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 종양 혈관신생 억제 연구에 유용합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 2 µg/mL | View 2 publications |
| Immunohistochemistry (IHC) | - | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 | - |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptides corresponding to residues R(1718)RL M E S Y C E T W R T E(1731) of Mouse Endostatin and R(1699)R L T E S Y C E T W R T E(1712) of Human Endostatin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2245014 |
Product Specific Information
- PA1-601 detects recombinant human and mouse endostatin.
- Suitable for Western blot, IF/ICC, and IHC (P) applications.
- Detects a 20 kDa protein representing recombinant human endostatin in Western blot.
- Immunizing peptides derived from amino acid residues 129–142 of endostatin.
- Can be used with blocking peptide PEP-112.
Target Information
Endostatin induces non-uniform responses in endothelial cell proliferation, adhesion, and migration. It inhibits angiogenesis and tumor growth in vivo by inducing apoptosis in endothelial cells. Local delivery of endostatin specifically affects tumor-associated microvessels by reducing vessel density, diameter, and functionality.
Endostatin is non-toxic, does not induce drug resistance, and is considered a potential therapeutic strategy for solid tumors, including gliomas.
Its anti-angiogenic effect is partly mediated by Zn²⁺ binding and elastase processing. Endostatin is also found in elastic fibers of vessel walls and basement membranes and accumulates in amyloid plaques in Alzheimer’s disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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