Thermo Fisher Scientific CD74 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Immunogen sequence:
PKPVSKMRMA TPLLMQALPM GALPQGPMQN ATKYGNMTED HVMHLLQNAD PLKVYPPLKG SFPENLRHLK NTMETIDWKV FESWMHHWLL FEMSRHSLEQ KPTDAPPK

Target Information

HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons: exon 1 encodes the leader peptide, exons 2 and 3 encode the extracellular domains, and exon 4 encodes the transmembrane domain and cytoplasmic tail.
DRA acts as the sole alpha chain for DRB1, DRB3, DRB4, and DRB5. The beta chain contains polymorphisms specifying peptide binding specificities. Hundreds of DRB1 alleles have been described, and typing for these polymorphisms is routinely performed for bone marrow and kidney transplantation.
HLA-DR is expressed primarily on antigen-presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells, and activated T lymphocytes. DR, DQ, and DP loci encode the major expressed products of the human class II region. These molecules bind intracellularly processed peptides and present them to T-helper cells, playing a critical role in immune response initiation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.