Thermo Fisher Scientific FAS Polyclonal Antibody
Rabbit polyclonal antibody targeting human FAS (CD95) for Western blot applications. Synthetic peptide immunogen within amino acids 153–248. High purity via antigen affinity chromatography. Suitable for apoptosis and cell signaling studies.
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Applications
- Western Blot (WB): Tested dilution 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region within amino acids 153–248 of Human CD95 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.7 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | 0.1M tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2548061 |
Product Specific Information
- Recommended positive controls: K562, THP-1
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
FAS (Fas, CD95, APO-1) is a 46 kDa transmembrane glycoprotein functioning as a cell death receptor of the TNFR superfamily. It also exists in a soluble form (~26 kDa). Activation of FAS induces aggregation of FAS-associated death domains (FADD), formation of the death-inducing signaling complex (DISC), and activation of caspases leading to apoptosis. FAS can activate NF-kappaB, MAPK3/ERK1, MAPK8/JNK pathways, and is involved in proliferation signaling in fibroblasts and T cells. Multiple alternatively spliced variants exist, some lacking the transmembrane domain, which may negatively regulate apoptosis. The Fas/Fas ligand system plays roles in diseases such as AIDS, hepatitis, and cancer, and is important in antiviral immune responses.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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