Thermo Fisher Scientific Brevican Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.01-3 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

5-30 µg/mL

-

Immunocytochemistry (ICC/IF)

5-30 µg/mL

-

Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein Brevican. The antigen corresponds to amino acid range 23-353 of the target protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Brevican,uniProtId:Q61361-1,ncbiNodeId:10090,antigenRange:23-353,antigenLength:883,antigenImageFileName:PA5-118986_Brevican_Q61361-1_Rabbit.svg,antigenImageFileNamePDP:PA5-118986_Brevican_Q61361-1_Rabbit_PDP.jpeg,sortOrder:3}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.6 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2903486

Target Information

Brevican is the most abundant chondroitin sulfate proteoglycan in the extracellular matrix of the adult brain. It is a member of the lectican family of aggregating extracellular matrix proteoglycans that bear chondroitin sulfate (CS) chains. It is highly expressed in the central nervous system and is thought to stabilize synapses and inhibit neural plasticity. Brevican is secreted from astrocytes and neurons as a 145 kD core protein that bears up to three, covalently-linked, CS chains. It is also is secreted as a 145 kD core protein without CS chains. When cleaved by extracellular glutamyl endopeptidases, the ADAMTSs, a 55 kD N-terminal fragment is formed that contains the unique C terminal epitope EAMESE.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.