Thermo Fisher Scientific Human Nanog Synthetic Peptide
인간 NANOG 단백질 중심부 19개 아미노산 서열에 해당하는 합성 펩타이드. 항체 PA5-20889의 차단용으로 사용 가능. 배아줄기세포의 다능성 연구에 활용. 액상 형태, PBS 완충액 내 0.1% BSA 함유, -20°C 보관.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 19 amino acids near the center of human NANOG.
PEP-1003 can be used as a blocking peptide with polyclonal antibody PA5-20889.
Target Information
NANOG (Nanog homeobox) is a divergent homeodomain protein that directs pluripotency and differentiation of undifferentiated embryonic stem cells. NANOG mRNA is present in pluripotent mouse and human cell lines, and absent from differentiated cells. Human NANOG protein shares 52% overall amino acid identity with the mouse protein, and 85% identity in the homeodomain. Human NANOG maps to gene locus 12p13.31, while the mouse NANOG maps to gene loci 6 F2.
Murine embryonic NANOG expression is detected in the inner cell mass of the blastocyst. Research studies have shown that high levels of human NANOG expression occur in the undifferentiated N-Tera embryonal carcinoma cell line. Further, NANOG is a transcription regulator involved in inner cell mass and embryonic stem (ES) cell proliferation and self-renewal.
The role of NANOG in embryonic development suggests that it might be useful in the creation of stem cells for cell replacement therapies in degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing POU5F1 (Oct-4), Sox2, Klf4, Lin28, and c-Myc in mouse fibroblasts. Experiments have demonstrated that iPS cells could be generated using expression plasmids expressing NANOG, Sox2, Klf4, and c-Myc, eliminating the need for viral introduction, thereby addressing safety concerns for regenerative medicine.
When overexpressed, NANOG promotes cells to enter into S phase and proliferation. Diseases associated with dysfunction in the NANOG protein include teratocarcinoma and germ cell/embryonal cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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