Thermo Fisher Scientific Phospho-Jak2 (Tyr1007, Tyr1008) Recombinant Rabbit Monoclonal Antibody (JAK2Y10071008-PB6), PE
PE 형광으로 표지된 재조합 래빗 모노클로날 항체로, 인간 Phospho-Jak2 (Tyr1007, Tyr1008)를 검출에 사용. Flow Cytometry에 최적화되어 있으며, 고순도 Protein A/G 정제. 연구용으로만 사용 가능.
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Applications
- Flow Cytometry (Flow): 5 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JAK2Y10071008-PB6 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Tyr1007/Tyr1008 of human phospho Jak2 |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.20% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897131 |
Additional Formats
- Unconjugated: MA5-37196
- APC: MA5-37199
- FITC: MA5-37198
- Custom conjugation available
Target Information
Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in cytokine receptor signaling pathways and is mutated in polycythemia vera. This kinase contains the catalytic domain (JH1) of JAK2. Activation of JAKs leads to phosphorylation of STAT proteins, which dimerize and translocate to the nucleus to regulate transcription of various genes, including interferon-stimulated genes.
JAK2 is essential for the IFN gamma-receptor complex initiation, while JAK1 acts as an amplifier. Mutations in JAK2 can cause Budd-Chiari syndrome, Polycythemia vera, Thrombocythemia 3, myelofibrosis, or Acute myelogenous leukemia.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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배송 정보
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