Thermo Fisher Scientific TCR V alpha 2 Monoclonal Antibody (F1), FITC
인간 및 비인간 영장류 반응성을 가진 TCR V alpha 2 단클론 항체로, FITC 형광 표지되어 있습니다. Flow Cytometry, IHC, WB 등 다양한 연구 응용에 적합합니다. 단백질 A 정제, PBS/BSA 완충액에 보관하며 4°C 암소 저장이 권장됩니다.
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Thermo Fisher Scientific TCR V alpha 2 Monoclonal Antibody (F1), FITC
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | View 1 publication |
| Immunohistochemistry (IHC) | - | View 4 publications |
| Flow Cytometry (Flow) | 1–2 µg/test | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Published Species | Human, Non-human primate |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | F1 |
| Immunogen | Human TCR V alpha-2 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.15 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 0.5% BSA |
| Contains | 0.1% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_417093 |
Additional Formats
Target Information
T cell receptors (TCRs) are essential for distinguishing foreign from self-peptides presented by MHC class II molecules, enabling effective adaptive immune responses. Recognition of self-peptides is associated with autoimmune diseases, while mutant self-peptides are linked to tumors. Superantigen engagement of TCRs can lead to toxic shock syndrome. Autoantibodies to TCR V beta segments have been found in rheumatoid arthritis and systemic lupus erythematosus patients, potentially modulating inflammatory responses.
Most human T cells express TCR alpha-beta and either CD4 or CD8 (single positive, SP). A smaller subset lacks both (double negative, DN), with increased alpha-beta DN T cells observed in autoimmune and immunodeficiency disorders. Gamma-delta T cells, primarily epithelial, exhibit limited TCR diversity and distinct antigen recognition, contributing to antitumor and immunoregulatory activity.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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