Thermo Fisher Scientific PD-L2/PDCD1LG2/CD273 Monoclonal Antibody (PDL2/1850)

Applications

• Flow Cytometry (Flow): 1–2 µg/10⁶ cells

Product Specifications

Target Information

Programmed death-ligand 2 (PD-L2), also known as B7-DC, is a member of the B7 ligand family within the immunoglobulin superfamily. Along with PD-L1, it acts as a ligand for programmed cell death protein 1 (PD-1).
PD-L2 is primarily expressed in dendritic cells but can be induced in various immune and non-immune cells depending on the microenvironment. Expression is particularly upregulated by Th2 cytokine IL-4 and, to a lesser degree, by Th1 cytokines TNF-α and IFN-γ.
Although PD-L2 is generally expressed at lower levels than PD-L1, it shows 2–6 times higher affinity for PD-1. PD-1 and its ligands act as inhibitory immune checkpoint molecules that provide negative feedback during immune homeostasis.
Binding of PD-L2 or PD-L1 inhibits T cell activation, proliferation, and cytokine secretion (e.g., IFN-γ, IL-10), thereby dampening immune responses. Interestingly, PD-L2 can also stimulate T cell proliferation and cytokine production even in PD-1-deficient T cells, suggesting additional receptor interactions.
Recent studies revealed that PD-L2 also binds to repulsive guidance molecule b (RGMb), which regulates respiratory tolerance in the lung through BMP and/or neogenin signaling pathways.
The human PD-L2 monomer consists of a 201-amino-acid extracellular domain, a 21-amino-acid transmembrane domain, and a 32-amino-acid cytoplasmic domain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.