Thermo Fisher Scientific PD-L2/PDCD1LG2/CD273 Monoclonal Antibody (PDL2/2676)

Applications and Tested Dilution

Product Specifications

Target Information

Programmed death-ligand 2 (PD-L2), also known as B7-DC, is a member of the B7 ligand family within the immunoglobulin superfamily. Along with PD-L1, it acts as a ligand for programmed cell death protein 1 (PD-1). PD-L2 is primarily expressed in dendritic cells but can be induced in various immune and non-immune cells depending on the microenvironment. Its expression is upregulated by cytokines such as IL-4, TNF-alpha, and IFN-gamma. Although expressed at lower levels than PD-L1, PD-L2 binds PD-1 with 2–6 times higher affinity.

PD-1 and its ligands function as inhibitory immune checkpoint molecules, providing negative feedback to regulate immune homeostasis. Binding of PD-L2 or PD-L1 to PD-1 inhibits T cell activation, proliferation, and cytokine secretion (e.g., IFN-gamma, IL-10). Interestingly, PD-L2 can also stimulate T cell proliferation independently of PD-1, suggesting additional receptor interactions. Recent studies identified repulsive guidance molecule b (RGMb) as another PD-L2 receptor, involved in respiratory tolerance via BMP and neogenin signaling pathways.

The human PD-L2 monomer consists of a 201-amino-acid extracellular domain, a 21-amino-acid transmembrane domain, and a 32-amino-acid cytoplasmic domain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.