Thermo Fisher Scientific UBE2C Polyclonal Antibody
Thermo Fisher Scientific의 UBE2C Polyclonal Antibody는 인간, 마우스, 랫트 시료에 반응하며, 다양한 응용(WB, IHC, ICC/IF, ELISA, IP)에 적합합니다. 고순도 친화 크로마토그래피 정제, 안정적 액상 형태, -20°C 보관 조건으로 높은 재현성과 신뢰성을 제공합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
| Immunoprecipitation (IP) | 0.5 µg–4 µg antibody for 200 µg–400 µg extracts |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 1–179 of human UBE2C (NP_008950.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.79 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901649 |
Product Specific Information
- Positive Samples: 22Rv1, THP-1, U-87MG, SW620, SKOV3
- Immunogen Sequence:
MASQNRDPAA TSVAAARKGA EPSGGAARGP VGKRLQQELM TLMMSGDKGI SAFPESDNLF KWVGTIHGAA GTVYEDLRYK LSLEFPSGYP YNAPTVKFLT PCYHPNVDTQ GNICLDILKE KWSALYDVRT ILLSIQSLLG EPNIDSPLNT HAAELWKNPT AFKKYLQETY SKQVTSQEP
Target Information
This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression and may be involved in cancer progression.
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, catalyzes Lys-11- and Lys-48-linked polyubiquitination.
Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis.
Initiates Lys-11-linked polyubiquitin chains on APC/C substrates, leading to their degradation by the proteasome and promoting mitotic exit.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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