Thermo Fisher Scientific Glypican-3 (GPC3) (Hepatocellular Carcinoma Marker) Monoclonal Antibody (SPM595)
인간 GPC3 단백질을 인식하는 SPM595 클론의 단일클론 항체로 간세포암종 표지 연구에 적합. IHC, ICC/IF, Flow Cytometry 등 다양한 응용 가능. Protein A/G 정제, PBS 버퍼에 0.05% BSA 및 sodium azide 포함. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SPM595 |
| Immunogen | Recombinant fragment containing amino acids 511–580 of human Glypican-3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Target Information
GPC3 is a cell surface proteoglycan that bears heparan sulfate. It may be involved in suppression and modulation of growth in mesodermal tissues and organs, and may play a role in regulating IGF2 interactions with its receptor. Members of the glypican family contain a core protein anchored to the membrane via a glycosyl phosphatidylinositol (GPI) linkage, contributing to cell division and tumor predisposition regulation. Deletion mutations in GPC3 cause Simpson-Golabi-Behmel syndrome (SGBS), characterized by pre- and postnatal overgrowth with visceral and skeletal anomalies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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