Thermo Fisher Scientific CD122 Monoclonal Antibody (TM-b1 (TM-beta1)), FITC, eBioscience

Thermo Fisher Scientific CD122 Monoclonal Antibody (TM-b1 (TM-beta1)), FITC, eBioscience™

Applications and Tested Dilution

• Application: Flow Cytometry
• Tested Dilution: 0.5 µg/test
• Publications: View 4 publications

Product Specifications

Available Formats

• Unconjugated
• APC
• Biotin
• eFluor 450
• Functional Grade
• PE
• PE-Cyanine7
• PerCP-eFluor 710
• Super Bright 436
• Request custom conjugation

Product Specific Information

The TM-b1 monoclonal antibody reacts with mouse CD122, the 90–110 kDa interleukin-2 receptor beta chain (IL-2Rβ). CD122 is expressed by NK cells and some T cells in the periphery and is upregulated upon activation. It associates with CD25 and CD132 (common gamma chain) to form the high-affinity IL-2 receptor. TM-b1 inhibits high-affinity IL-2 binding.

• Applications Reported: Flow cytometric analysis
• Applications Tested: Flow cytometric analysis of mouse splenocytes
• Recommended Usage: ≤ 0.5 µg/test (100 µL final volume)
• Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser
• Filtration: 0.2 µm post-manufacturing filtered

Target Information

CD122 (Interleukin 2 receptor) is involved in T cell-mediated immune responses and is primarily expressed in the hematopoietic system. It exists in three forms:

1. Low-affinity monomer (alpha subunit)
2. Intermediate-affinity heterodimer (alpha/beta)
3. High-affinity heterotrimer (alpha/beta/gamma)

Both intermediate and high-affinity forms mediate endocytosis and mitogenic signal transduction. CD122 encodes the beta subunit, a type I membrane protein. Dysfunction is associated with oligoarticular juvenile idiopathic arthritis and rheumatoid factor-negative juvenile idiopathic arthritis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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