Thermo Fisher Scientific ACE2 Monoclonal Antibody (OTI2G7)
인간 ACE2 단백질을 표적으로 하는 단클론 항체로, Western blot과 IHC(Paraffin) 실험에 적합합니다. 고순도 Affinity Chromatography로 정제되었으며, 안정적인 PBS 기반 저장 버퍼를 제공합니다. 심혈관 및 바이러스 연구용으로 활용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
- Publications: View 1 publication
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:500
- Publications: View publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2G7 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 18–237 of ACE2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2723830 |
Target Information
Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. ACE2 is also known as a functional receptor of the SARS coronavirus.
The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. Lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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