Thermo Fisher Scientific ACE2 Monoclonal Antibody (OTI4D2)
ACE2 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체. Western blot 및 IHC(P)에서 검증됨. 인간 시료 반응성, Mouse IgG2a 형. 액상, 1 mg/mL 농도, PBS/BSA/glycerol buffer. -20°C 보관, 연구용 전용.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:200 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4D2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 18–237 of ACE2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2723831 |
Target Information
Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology.
In contrast to its homolog ACE, ACE2 expression is restricted to the heart, kidney, and testis.
ACE2 has also been identified as a functional receptor for the SARS coronavirus.
Its normal function is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII.
Lack of ACE2 expression in knockout mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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