Thermo Fisher Scientific Phospho-EGFR (Tyr1068) Recombinant Rabbit Monoclonal Antibody (EGFRY1068-E5), APC
APC 형광으로 결합된 Phospho-EGFR (Tyr1068) 특이 재조합 토끼 단일클론 항체. 인간 및 마우스 반응성. 높은 특이성과 로트 간 일관성 제공. Flow Cytometry에 적합하며, 암 관련 EGFR 신호 연구에 활용 가능.
- 카탈로그번호
- MA536968
- 판매단위
- pk
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Thermo Fisher Scientific Phospho-EGFR (Tyr1068) Recombinant Rabbit Monoclonal Antibody (EGFRY1068-E5), APC
Applications
- Flow Cytometry (Flow)
Tested Dilution: 5 µL/1x10^6 cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | EGFRY1068-E5 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Tyr1068 of human phospho EGFR |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2896903 |
Additional Formats
- Unconjugated (MA5-36965)
- FITC (MA5-36967)
- PE (MA5-36966)
- Custom conjugation available upon request
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone antibody DNA sequences from immunoreactive rabbits, and individual clones are screened to select optimal candidates.
Advantages include:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
EGFR (epidermal growth factor receptor) is a receptor tyrosine kinase that mediates signaling in response to various growth factors. Overexpression is associated with numerous cancers, and EGFR serves as a therapeutic target for both biological and small molecule drugs.
EGFR is encoded on chromosome 7 in humans and belongs to the HER/ERbB family, including ERbB2, ERbB3, and ERbB4. Ligand binding (e.g., EGF, TGFα) induces dimerization and autophosphorylation of tyrosine residues in the cytoplasmic domain. Overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, and squamous cell carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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