Thermo Fisher Scientific Proteasome 20S beta 6 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

Proteolytic degradation plays a critical role in maintaining proper levels of short-lived and regulatory proteins involved in processes such as cellular metabolism, stress response, antigen presentation, receptor modulation, cell cycle regulation, and signaling.
The ubiquitin-proteasome pathway is responsible for degrading most cytosolic and nuclear proteins in eukaryotic cells, while other proteins are degraded through the vacuolar pathway involving endosomes, lysosomes, and the endoplasmic reticulum.

The 26S proteasome is an ATP-dependent, multisubunit (~31) molecular complex (~2.5 MDa) composed of a 20S proteolytic core and one or two 19S regulatory subunits. The 19S subunits recognize ubiquitinated proteins and facilitate their unfolding and translocation into the 20S core. The PA28/11S REG Activator complex, consisting of alpha, beta, and gamma subunits, enhances 20S proteolytic activity.

Defects in the ubiquitin-proteasome pathway are associated with several genetic diseases, including cystic fibrosis (CF transmembrane regulator), Angelman’s syndrome (E6-AP), and Liddle syndrome (endothelial sodium channels).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.