Thermo Fisher Scientific 4EBP1 Polyclonal Antibody
Human, Mouse, Rat 반응성을 가지는 Rabbit Polyclonal 4EBP1 항체. Western Blot 및 IHC(P) 실험에 사용 가능. 고순도(>95%) 항원 친화 크로마토그래피 정제. 장기 보관 시 -20°C에서 냉동 보관 권장.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
- Publications: –
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
- Publications: –
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 17–60 of Human 4E-BP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803374 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
This gene encodes a member of the translation repressor protein family. The 4EBP1 protein interacts directly with eukaryotic translation initiation factor 4E (eIF4E), a key component of the complex that recruits 40S ribosomal subunits to the 5′ end of mRNAs. Interaction with eIF4E inhibits complex assembly and represses translation. Phosphorylation of 4EBP1 in response to signals such as UV irradiation and insulin leads to its dissociation from eIF4E and activation of mRNA translation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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