Thermo Fisher Scientific PON1 Polyclonal Antibody
Thermo Fisher Scientific의 PON1 Polyclonal Antibody는 인간 및 마우스 반응성을 가지며, Western blot과 IHC에 적합합니다. 항원 친화 크로마토그래피로 정제된 액상 항체로, 1 mg/mL 농도를 유지합니다. 연구용으로 인간 PON1 단백질 검출에 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | 1 publication |
| Miscellaneous PubMed (Misc) | - | 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Full length human PON1 recombinant protein (aa 1–355) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2546473 |
Product Specific Information
- Recommended positive controls: human plasma, human liver, HepG2
- Predicted reactivity: Mouse (82%), Rat (81%), Pig (84%), Rabbit (85%), Bovine (82%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The paraoxonase (PON) gene family in humans includes PON1, PON2, and PON3, located on chromosome 7q21.3–22.1.
PON1 is primarily synthesized in the liver and secreted into plasma, where it associates with high-density lipoproteins (HDL).
It hydrolyzes active metabolites of organophosphorus insecticides (e.g., chlorpyrifos oxon, diazoxon) and nerve agents such as sarin, soman, and VX.
PON1 polymorphisms are linked to neurodegeneration and may serve as an independent risk factor for Parkinson’s disease.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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