Thermo Fisher Scientific PDCD5 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:1,000

Product Specifications

Product Specific Information

• Recommended positive controls: A549, HeLa, HCT116
• Predicted reactivity: Mouse (95%), Rat (96%), Zebrafish (80%), Chicken (84%), Rhesus Monkey (100%), Bovine (95%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Programmed cell death 5 (PDCD5) is a human apoptosis-related protein that plays an early and universal role in apoptosis. PDCD5 is widely expressed and upregulated in cells undergoing apoptosis, translocating rapidly from the cytoplasm to the nucleus. It has a compact core structure with two mobile N-terminal alpha-helices and a flexible unstructured C-terminal region. Charged residues are essential for apoptosis promotion and cell translocation. PDCD5 facilitates apoptosis and enhances TAJ/TROY-induced paraptosis-like cell death. It may act as a Tip60 co-activator promoting apoptosis and could serve as a tumor suppressor gene influencing lung cancer susceptibility.

⚠ WARNING: This product can expose you to chemicals including mercury, known to cause birth defects or other reproductive harm.
For more information: www.P65Warnings.ca.gov

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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