Thermo Fisher Scientific PSPN Polyclonal Antibody
Rabbit polyclonal antibody targeting human Persephin (PSPN). Suitable for Western blot and ELISA applications. High specificity and affinity-purified. Supplied as liquid form with stabilizing buffer for long-term storage.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1:20,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from the C-terminal region of human PSP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2636548 |
Product Specific Information
Persephin Polyclonal Antibody detects endogenous levels of Persephin protein.
Target Information
Persephin is a disulfide-linked, homodimeric neurotrophic factor structurally related to GDNF, artemin, and neurturin. These proteins belong to the cysteine-knot family of growth factors that form stable dimeric structures. Persephin signals through a multicomponent receptor system composed of RET and one of four GFR alpha (α1–α4) receptors. GFRα4, first identified in chicken, is the preferential binding subunit for Persephin. Persephin promotes the survival of ventral midbrain dopaminergic neurons and motor neurons after sciatic nerve axotomy, and, like GDNF, promotes ureteric bud branching. However, unlike GDNF and neurturin, Persephin does not support the survival of peripheral neurons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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