Thermo Fisher Scientific NUP107 Polyclonal Antibody
Thermo Fisher Scientific의 NUP107 Polyclonal Antibody는 인간 및 흰쥐 시료에 반응하며, Western blot과 Immunocytochemistry에 적합합니다. 항원 친화 크로마토그래피로 정제된 비결합 액상 항체로, 세포 내 핵공복합체 연구에 활용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1–2 µg/mL
Immunocytochemistry (ICC/IF)
- Tested Dilution: 2.5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 15 amino acid peptide from near the carboxy terminus of human NUP107 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154672 |
Product Specific Information
- Suggested positive control: A549 cell lysate
- PA5-20563 can be used with blocking peptide PEP-0683.
Target Information
The nuclear pore complex (NPC) is a protein assembly localized at the nuclear rim and mediates macromolecular transport between the nucleus and the cytoplasm.
The mammalian nucleoporin (NUP)-107 is part of a hetero-oligomeric complex containing NUP160, NUP133, NUP96, and the mammalian homolog of yeast sec13p.
A fraction of the NUP107-160 complex localizes to kinetochores and pro-metaphase spindle poles in mitotic cells, associated with proteins such as Mad1, Mad2, Bub3, and Cdc20.
Immunodepletion of the NUP107-160 complex results in defective spindle assembly, indicating multiple functions.
NUP107 has been identified as an HIV dependency factor (HDF), suggesting potential as a drug target in HIV treatment. Multiple isoforms of NUP107 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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