Thermo Fisher Scientific SATB2 Polyclonal Antibody
SATB2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC, ELISA 등 다양한 응용에 적합. Human, Mouse, Rat 반응성 보유. 고순도 Protein A 정제, 안정적 액상 형태로 연구용에 최적화.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human SATB2, amino acids 451–485 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
DNA-binding protein SATB2 binds to DNA at nuclear matrix- or scaffold-associated regions and recognizes the sugar-phosphate structure of double-stranded DNA. It acts as a transcription factor controlling nuclear gene expression by binding to matrix attachment regions (MARs) and inducing chromatin-loop remodeling. SATB2 serves as a docking site for chromatin remodeling enzymes by recruiting corepressors (HDACs) or coactivators (HATs) to promoters and enhancers. It is essential for initiating the upper-layer neuron-specific genetic program and repressing deep-layer neuron genes, likely via modulation of BCL11B expression. SATB2 is a repressor of Ctip2 and a key determinant of corticocortical connections in the developing cerebral cortex. Mutations in SATB2 are associated with cleft palate isolated (CPI).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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