Thermo Fisher Scientific POLE3/CHRAC17 Monoclonal Antibody (PCRP-POLE3-2F10)
Thermo Fisher Scientific의 POLE3/CHRAC17 단클론 항체(PCRP-POLE3-2F10)는 인간 POLE3 단백질을 인식하는 Mouse IgG1 항체로, IHC, ICC/IF, Flow Cytometry 등 다양한 응용에 적합합니다. 단백질 A/G로 정제된 액상 형태이며, 연구용으로 사용됩니다.
- 카탈로그번호
- 54107-MSM2-P1ABX
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PCRP-POLE3-2F10 |
| Immunogen | Recombinant full-length human POLE3 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Immunohistochemistry (PFA fixed): incubate antibody for 30 minutes at room temperature.
Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
Mitochondrial creatine kinase (MtCK) is responsible for transferring high-energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family and exists as two isoenzymes—sarcomeric MtCK and ubiquitous MtCK—encoded by separate genes.
MtCK occurs in two oligomeric forms: dimers and octamers, unlike the exclusively dimeric cytosolic creatine kinase isoenzymes. Sarcomeric MtCK shows 80% homology with the coding exons of ubiquitous MtCK.
This gene contains sequences homologous to motifs shared among nuclear genes encoding mitochondrial proteins, which may be essential for coordinated activation during mitochondrial biogenesis. Three transcript variants encoding the same protein have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: 54107-MSM2-P1ABX_POLE3_Q9NRF9-1_House_mouse.svg, 54107-MSM2-P1ABX_POLE3_Q9NRF9-1_House_mouse_PDP.jpeg)
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