Thermo Fisher Scientific RET Monoclonal Antibody (421R25)
RET 단백질을 표적하는 마우스 단클론 항체로 Western blot에 적합합니다. 인간, 마우스, 랫트에 반응하며, 0.5 mg/mL 농도의 액상 형태로 제공됩니다. Affinity chromatography로 정제되었으며, 신경능선 발달 및 종양 관련 연구에 활용 가능합니다.
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Applications
- Western Blot (WB): 1–3 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 421R25 |
| Immunogen | Recombinant fragment of human c-Ret extracellular domain expressed in E. coli. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 1% BSA |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2536342 |
Target Information
The receptor tyrosine kinase RET is a member of the cadherin superfamily and plays a crucial role in neural crest development. RET can undergo oncogenic activation via cytogenetic rearrangement and transduces signals for cell growth and differentiation.
Mutations in the RET gene are associated with multiple endocrine neoplasia (types IIA and IIB), Hirschsprung disease, and medullary thyroid carcinoma.
Two transcript variants encoding different isoforms have been identified, with additional variants of uncertain biological relevance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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