ELK Biotechnology RASL1 rabbit pAb
RASL1 단백질에 특이적인 rabbit polyclonal antibody로서 WB와 ELISA에 적합합니다. 인간 및 생쥐 시료에서 반응하며, 세포질 및 세포막 내측에 위치한 단백질 검출에 유용합니다. 고농도(1 mg/ml)로 제공되며, -20°C에서 1년간 안정적으로 보관 가능합니다.
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RASL1 rabbit pAb
공급업체: ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | RASL1 rabbit pAb |
| Applications | WB; ELISA |
| Recommended Dilutions | WB: 1:500–2000 / ELISA: 1:5000–20000 |
| Immunogen | Synthesized peptide derived from human protein (AA range: 170–250) |
| Species Reactivity | Human; Mouse |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 88 kD |
| GeneID (Human) | 8437 |
| Human Swiss-Prot No | O95294 |
| Cellular Localization | Intracellular, cytosol, plasma membrane, intrinsic component of the cytoplasmic side of the plasma membrane |
| Storage | -20°C / 1 year |
Background
The protein encoded by this gene is a member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins, resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This family member contains domains characteristic of the GAP1 subfamily of RasGAP proteins but, unlike other GAP1 family members, is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants encoding different isoforms have been described (RefSeq, Jul 2010).
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