ELK Biotechnology RASL2 rabbit pAb
RASL2 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 ELISA에 적합합니다. 세포막과 세포질 내 RAS 신호 조절 연구에 활용 가능하며, 고순도 IgG 형태로 제공됩니다. -20°C에서 1년간 안정적으로 보관할 수 있습니다.
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RASL2 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | RASL2 rabbit pAb |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–1:2000, ELISA 1:5000–1:20000 |
| Immunogen | Synthesized peptide derived from human protein (AA range: 100–180) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 88 kDa |
| GeneID (Human) | 10156 |
| Human Swiss-Prot No. | O43374 |
| Cellular Localization | Cytoplasm, cytosol, and cell membrane; peripheral membrane protein. Localized to the cytosol due to lack of phosphoinositide binding activity. Upon agonist-stimulated calcium mobilization, utilizes C2A and C2B domains to associate with the plasma membrane. |
| Species Reactivity | Human; Mouse |
Background
This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca²⁺. Stimuli that increase intracellular Ca²⁺ levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. (Provided by RefSeq, Jul 2008)
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