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ELK Biotechnology TRIPC rabbit pAb
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ELK Biotechnology TRIPC rabbit pAb

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인간, 생쥐, 랫트 시료에 반응하는 TRIPC 단백질 특이 토끼 폴리클로날 항체. WB 및 ELISA에 사용 가능하며, 고농도(1 mg/ml)로 제공. 핵 및 핵질에 주로 존재하는 단백질 검출에 적합. -20°C에서 1년 보관 가능.

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pk
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ELK Biotechnology ES10049-100UL TRIPC rabbit pAb, 100UL pk판매 단위 pk ·
재고 확인 필요
402,000원VAT 포함 442,200원
ELK Biotechnology ES10049-50UL TRIPC rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원

ELK Biotechnology · ELK Biotechnology TRIPC rabbit pAb

ELK Biotechnology TRIPC rabbit pAb

제품 정보

항목 내용
Product name TRIPC rabbit pAb
Applications WB; ELISA
Recommended Dilutions WB 1:500–1:2000, ELISA 1:5000–1:20000
Immunogen Synthesized peptide derived from human protein (AA range: 950–1030)
Host Rabbit
Storage -20°C, 1 year
Clonality Polyclonal
Isotype IgG
Concentration 1 mg/ml
Observed Band 219 kDa
GeneID (Human) 9320
Human Swiss-Prot No Q14669
Cellular Localization Nucleus, nucleoplasm
Species Reactivity Human; Rat; Mouse

Background

Component of PA700, an ATP-dependent multisubunit protein that activates the proteolytic activities of the multifunctional proteinase (20S proteasome) of the 26S complex. Specifically interacts with the ligand-binding domain of the thyroid hormone receptor (in a thyroid hormone T3-independent manner) and with retinoid X receptor (RXR).
Could be an E3 ubiquitin-protein ligase that accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

  • Miscellaneous: A cysteine residue is required for ubiquitin-thioester formation.
  • Pathway: Protein modification; protein ubiquitination.
  • PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Similarity: Belongs to the UPL family, K-HECT subfamily. Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain and 1 WWE domain.
  • Subunit: PA700 is composed of at least 16 distinct peptides ranging from 20–112 kDa.

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