ELK Biotechnology OAZ3 rabbit pAb
OAZ3 단백질을 인식하는 토끼 다클론 항체로, WB 및 ELISA에 적합합니다. 인간, 생쥐, 랫드 시료에 반응하며, 세포 내 핵과 세포질에서 발현됩니다. 세포 성장 조절 및 정자 형성과 관련된 연구에 활용 가능합니다.
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ELK Biotechnology OAZ3 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | OAZ3 rabbit pAb |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from human protein (AA range: 90–170) |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 20 kD |
| Gene ID (Human) | 51686 |
| Human Swiss-Prot No. | Q9UMX2 |
| Cellular Localization | Nucleus, Cytoplasm |
| Species Reactivity | Human, Rat, Mouse |
Background
The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which regulates intracellular polyamine levels to control cell growth and proliferation. Expression of antizymes requires +1 ribosomal frameshifting, enhanced by high polyamine levels. Antizymes bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis, forming an auto-regulatory circuit.
This gene encodes antizyme 3, the third member of the family. Like antizymes 1 and 2, antizyme 3 inhibits ODC activity and polyamine uptake but does not promote ODC degradation. Unlike the broadly distributed antizymes 1 and 2, antizyme 3 expression is restricted to haploid germ cells in the testis, suggesting a specialized role in spermiogenesis.
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