ELK Biotechnology MYO7A rabbit pAb

ELK Biotechnology MYO7A rabbit pAb

제품 설명

MYO7A 단백질을 인식하는 토끼 유래 다클론 항체로, Western Blot(WB) 및 ELISA 실험에 사용됩니다. 인간 및 생쥐 시료에서 반응하며, 세포질 및 세포골격 부위에 주로 발현됩니다.

제품 정보

세포 내 위치 (Cellular Localization)

Cytoplasm, cytoplasm cell cortex, cytoskeleton, cell junction, synapse.
In photoreceptor cells, mainly localized in the inner and base of outer segments as well as in the synaptic ending region (PubMed:8842737).
In retinal pigment epithelial cells, colocalizes with a subset of melanosomes, predominantly localized to stress fiber-like structures and cytoplasmic puncta (PubMed:19643958, PubMed:27331610).
Detected at the tip of cochlear hair cell stereocilia (PubMed:21709241).
The complex formed by MYO7A, USH1C, and USH1G colocalizes with F-actin (PubMed:21709241).

Background

This gene is a member of the myosin gene family. Myosins are mechanochemical proteins characterized by the presence of a motor domain, an actin-binding domain, a neck domain that interacts with other proteins, and a tail domain that serves as an anchor.
This gene encodes an unconventional myosin with a very short tail. Defects in this gene are associated with the mouse shaker-1 phenotype and the human Usher syndrome 1B, which are characterized by deafness, reduced vestibular function, and (in humans) retinal degeneration.
Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]