ELK Biotechnology MRP1 rabbit pAb
MRP1 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 ELISA에 적합합니다. 인간, 랫드, 마우스 시료에 반응하며 세포막 다중 통과 단백질을 검출할 수 있습니다. 고순도 IgG 형태로 -20°C에서 1년간 안정적으로 보관 가능합니다.
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제품명
MRP1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–1:2000, ELISA 1:5000–1:20000 |
| Immunogen | Synthesized peptide derived from human protein (AA range: 110–190) |
| Species Reactivity | Human; Rat; Mouse |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 168 kD |
| Gene ID (Human) | 4363 |
| Human Swiss-Prot No. | P33527 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein |
| Storage | -20°C, 1 year |
Background
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
This full transporter is a member of the MRP subfamily, which is involved in multi-drug resistance. The protein functions as a multispecific organic anion transporter, with oxidized glutathione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. It also transports glucuronides and sulfate conjugates of steroid hormones and bile salts.
Alternatively spliced variants of this gene have been described, but their full-length nature is unknown.
[Provided by RefSeq, Apr 2012]
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