ELK Biotechnology MDR3 rabbit pAb
MDR3 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 ELISA에 적합합니다. 인간, 랫드, 마우스 시료에 반응하며, 세포막 및 세포질 내 다중막 단백질 검출에 활용됩니다. -20°C에서 1년간 안정적으로 보관 가능합니다.
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제품명
MDR3 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from human protein (AA range: 20–100) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 141 kDa |
| Gene ID (Human) | 5244 |
| Human Swiss-Prot No | P21439 |
| Species Reactivity | Human; Rat; Mouse |
세포 내 위치 (Cellular Localization)
Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Membrane raft. Cytoplasm. Cytoplasmic vesicle, clathrin-coated vesicle.
Localized at the apical canalicular membrane of the epithelial cells lining the lumen of the bile canaliculi and biliary ductules (By similarity).
Transported from the Golgi to the apical bile canalicular membrane in a RACK1-dependent manner (PubMed:19674157).
Redistributed into pseudocanaliculi formed between cells in a bezafibrate- or PPARA-dependent manner (PubMed:15258199).
Localized preferentially in lipid nonraft domains of canalicular plasma membranes (PubMed:23468132).
배경 (Background)
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters.
ABC proteins transport various molecules across extra- and intra-cellular membranes.
ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
This protein is a member of the MDR/TAP subfamily, which is involved in multidrug resistance and antigen presentation.
The gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate.
Its function may involve transport of phospholipids from liver hepatocytes into bile.
Alternative splicing results in several products of undetermined function.
[Provided by RefSeq, Jul 2008]
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