Thermo Fisher Scientific PHLDA2 Polyclonal Antibody
PHLDA2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, ICC/IF, ELISA에 사용 가능. 고순도 Affinity Chromatography 정제, 인체 반응성, 액상 형태로 안정적 보관 가능. 세포막 및 세포질 단백질 검출에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:4,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 1–152 of human PHLDA2 (NP_003302.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.33 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806513 |
Product Specific Information
- Immunogen sequence: MKSPDEVLRE GELEKRSDSL FQLWKKKRGV LTSDRLSLFP ASPRARPKEL RFHSILKVDC VERTGKYVYF TIVTTDHKEI DFRCAGESCW NAAIALALID FQNRRALQDF RSRQERTAPA APAEDAVAAA AAAPSEPSEP SRPSPQPKPR TP
- Positive Samples: SW620, SKOV3, HeLa
- Cellular Location: Cytoplasm, Membrane, Peripheral membrane protein
Target Information
TSSC3 (Tumor-suppressing STF cDNA 3 protein), also known as PHLDA2 (pleckstrin homology-like domain family A member 2), BWR1C, HLDA2, or IPL, is a cytoplasmic protein involved in fetal and placental growth. It is highly expressed in placenta and adult prostate, and weakly expressed in liver, lung, and brain. TSSC3 functions as an apoptosis-related negative growth regulator during normal human development. The gene is maternally imprinted and expressed in placenta, liver, and fetal tissues during embryogenesis, being silenced after development. Mutations or dysregulation of TSSC3 are associated with lung, ovarian, and breast cancers, rhabdomyosarcoma, Beckwith-Wiedemann syndrome, Wilms tumor, low birth weight, and adrenocortical carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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