ELK Biotechnology LRBA rabbit pAb
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| Product name: | LRBA rabbit pAb |
| Applications: | IHC;IF |
| Recommended Dilutions: | IHC-p 1:50-300 |
| Immunogen: | Synthesized peptide derived from human protein . at AA range: 1970-2050 |
| Storage: | Rabbit |
| Storage: | -20°C/1 year |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Concentration: | 1 mg/ml |
| Observed Band: | 314kD |
| GeneID（Human）: | 987 |
| Human Swiss-Prot No: | P50851 |
| Cellular localization: | Cell membrane ; Single-pass membrane protein . Endoplasmic reticulum membrane ; Single-pass membrane protein . Golgi apparatus, trans-Golgi network membrane ; Single-pass membrane protein . Lysosome membrane ; Single-pass membrane protein . |
| Background: | The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012], |
| Species Reactivity: | Human;Mouse |
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