ELK Biotechnology KI2L2 rabbit pAb
KI2L2 rabbit polyclonal antibody for WB and ELISA applications. Recognizes human, rat, and mouse proteins. Derived from synthesized human peptide, stored at -20°C for up to 1 year. Provides reliable detection of KIR family membrane proteins.
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KI2L2 Rabbit Polyclonal Antibody
Supplier: ELK Biotechnology
Product Name: KI2L2 rabbit pAb
제품 스펙
| 항목 | 내용 |
|---|---|
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000; ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 38 kD |
| Gene ID (Human) | 3803 |
| Human Swiss-Prot No. | P43627 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein |
| Species Reactivity | Human; Rat; Mouse |
Background
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous, located on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC).
The gene content of the KIR cluster varies among haplotypes, but several framework genes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2) are found in all haplotypes.
KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by the length of their cytoplasmic domain (L or S). Proteins with long cytoplasmic domains transduce inhibitory signals via immune tyrosine-based inhibitory motifs (ITIM), while those with short domains lack this function.
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