ELK Biotechnology IPO5 rabbit pAb
IPO5 단백질을 인식하는 토끼 폴리클로날 항체로, WB와 ELISA에 적합합니다. 인간과 생쥐 시료에서 반응하며, 세포질 및 핵(특히 핵막과 인)에서 발현되는 단백질 연구에 활용됩니다. -20°C에서 1년 보관 가능합니다.
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ELK Biotechnology IPO5 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | IPO5 rabbit pAb |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 120 kD |
| Gene ID (Human) | 3843 |
| Human Swiss-Prot No. | O00410 |
| Cellular Localization | Cytoplasm, Nucleus, Nucleolus, Nuclear rim. Found particularly in the nuclear rim and nucleolus. |
| Species Reactivity | Human; Mouse |
Background
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits (karyopherins). Importin alpha binds the NLS-containing cargo in the cytoplasm, while importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP-binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein, and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex.
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