Thermo Fisher Scientific CD254 (RANK Ligand) Polyclonal Antibody

Product Specifications

Product Specific Information

Immunogen sequence:
PNRISEDGTH CIYRILRLHE NADFQDTTLE SQDTKLIPDS CRRIKQAFQG AVQKELQHIV GSQHIRAEKA MVDGSWLDLA KRSKLEAQPF AHLTINATDI PSGSHKVSLS SWYHDRGWAK ISNMTF

Target Information

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation.
This protein acts as a dendritic cell survival factor and regulates T cell-dependent immune responses.
T cell activation induces expression of this gene, leading to increased osteoclastogenesis and bone loss.
It activates antiapoptotic kinase AKT/PKB via a signaling complex involving SRC kinase and TRAF6, suggesting a role in apoptosis regulation.
Gene disruption in mice results in severe osteopetrosis, absence of osteoclasts, defects in T/B lymphocyte differentiation, and failure to form mammary structures during pregnancy.
Two alternatively spliced transcript variants have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.