Thermo Fisher Scientific Phospho-CD18 (Thr758) Polyclonal Antibody
인간 CD18 단백질 Thr758 인산화 부위를 인식하는 Rabbit Polyclonal Antibody. Western blot 및 Immunocytochemistry에 적합하며, 액상 형태로 제공. 세포 접착 및 신호전달 연구용으로 사용 가능. -20°C 보관, RRID: AB_2555044.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human CD18/ITGB2 around the phosphorylation site of Thr758 (S-A-TP-T-T) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555044 |
Target Information
CD18 integrin beta 2 subunit is a 90 kDa type I transmembrane protein expressed on all leucocytes.
It combines with integrin molecules CD11a–c to form heterodimers at the cell surface, participating in cell adhesion and signaling.
CD18 forms heterodimers with four types of CD11 molecules to constitute leukocyte (beta2) integrins:
- αLβ2 (CD11a/CD18, LFA-1)
- αMβ2 (CD11b/CD18, Mac-1, CR3)
- αXβ2 (CD11c/CD18)
- αDβ2 (CD11d/CD18)
These integrins are essential for proper leukocyte migration and intercellular contact mediation.
Absence or severe reduction of CD18 expression can lead to leukocyte adhesion deficiency type I (LAD1) or psoriasiform skin disease.
CD18 is also targeted by Mannheimia haemolytica leukotoxin, mediating leukotoxin-induced cytolysis.
Two transcript variants encoding the CD18 protein have been identified.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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