Thermo Fisher Scientific PPAR delta Polyclonal Antibody
PPAR delta 단백질을 인식하는 염소 유래 다클론 항체로, Western blot 및 IHC(P) 분석에 적합합니다. 인간에 반응하며, 서열 상 유사성 기반으로 소, 마우스, 돼지에서도 반응이 예측됩니다. TBS(pH 7.3) 버퍼에 0.5% BSA 포함, -20°C에서 보관합니다.
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- PA518299
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–3 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (CHPLLQEIYKDMY) corresponding to the C-terminus amino acids of PPARD (aa 432–441) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10983611 |
Product Specific Information
- This antibody is predicted to react with bovine, mouse, and porcine based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
The PPAR delta gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family, which are nuclear hormone receptors that regulate peroxisome proliferation and lipid metabolism. PPARs are involved in various biological processes and may play roles in chronic diseases such as diabetes, obesity, atherosclerosis, and cancer.
PPAR delta acts as an inhibitor of ligand-induced transcription activity of PPAR alpha and gamma, functioning as an integrator of transcription repression and nuclear receptor signaling. Elevated expression has been observed in colorectal cancer cells and can be repressed by the tumor suppressor APC. Mouse knockout studies suggest roles in myelination, lipid metabolism, and epidermal proliferation.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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