Thermo Fisher Scientific GTF2E1 Polyclonal Antibody
Rabbit polyclonal antibody against human GTF2E1. Suitable for ICC/IF applications. Antigen affinity purified with recombinant GTF2E1 fragment. Supplied in PBS with glycerol and sodium azide. For research use only.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human GTF2E1. Recombinant protein control fragment (Product #RP-107526) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2662756 |
Product Specific Information
Immunogen sequence:
RNSCVKEEDML ELLKFDRKQL RSVLNNLKGD KFIKCRMRVE TAADGKTTRH NYYFINYRTL VNVVKYKLDH MRRRIETDER DSTNRASFKC PVCSSTFTDL EANQLFDPMT GTFRCTFCHT EVEEDESAMP
Highest antigen sequence identity to the following orthologs:
- Mouse: 98%
- Rat: 95%
Target Information
The general transcription factor TFIIE plays an essential role in eukaryotic transcription initiation together with RNA polymerase II and other general factors. Human TFIIE consists of two subunits of relative molecular mass 57,000 (TFIIE-alpha) and 34,000 (TFIIE-beta) and joins the preinitiation complex after RNA polymerase II and TFIIF. TFIIE-alpha is necessary for transcription initiation together with TFIIE-beta, and recombinant TFIIE-alpha can fully replace the natural subunit in an in vitro transcription assay. Its sequence contains several structural motifs (leucine repeat, zinc finger, and helix-turn-helix) and sequence similarities to bacterial sigma factors, suggesting direct involvement in the regulation of transcription initiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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