Thermo Fisher Scientific SARS-CoV-2 Spike Protein (RBD) Recombinant Human Monoclonal Antibody (T01KHu)

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

5 µg/mL

View 1 publication 1 publication

Flow Cytometry (Flow)

1 µg/test

View 2 publications 2 publications

ELISA (ELISA)

0.2-2,000 ng/mL

View 1 publication 1 publication

Neutralization (Neu)

0.1-10 µg/mL

-

Luminex (LUM)

0.5 mg/mL

-

Not applicable (N/A)

-

View 1 publication 1 publication

Product Specifications

Species Reactivity

Virus

Published species

Human, Virus

Host/Isotype

Human / IgG1, kappa

Expression System

Expi293

Class

Recombinant Monoclonal

Type

Antibody

Clone

T01KHu

Immunogen

This antibody was developed using computationally derived variants of SARS-CoV antibody structures and is shown to bind Spike Protein S1 subunit (RBD) of SARS CoV2

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2866477

Product Specific Information

This antibody recognizes the RBD domain of SARS CoV2 Spike protein.

It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

This antibody is not recommended for the Western blot application.

Target Information

SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as 2019-nCoV (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold symptoms to severe effects including death and respiratory distress. The CoV Spike (S) protein plays the most important roles in viral attachment, fusion and entry, and serves as a target for development of antibodies, entry inhibitors and vaccines. Of note is the Spike protein receptor-binding domain (RBD, S-RBD) in SARS-CoV-2 Spike protein which binds strongly to human and bat angiotensin-converting enzyme 2 (ACE2) receptors. SARS-CoV-2 RBD exhibits significantly higher binding affinity to ACE2 receptor than SARS-CoV RBD in comparison. S1 contains a receptor-binding domain (RBD) that can specifically bind to angiotensin-converting enzyme 2 (ACE2), the receptor on target cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.