Thermo Fisher Scientific BAG3 Polyclonal Antibody
Thermo Fisher Scientific의 BAG3 Polyclonal Antibody는 인간 BAG3 단백질에 특이적으로 반응하는 Rabbit IgG 항체입니다. Western blot, IHC, ICC/IF에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human BAG3 (Product #RP-92058) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2638455 |
Product Specific Information
Immunogen sequence:
DCSSSSSSAS LPSSGRSSLG SHQLPRGYIS IPVIHEQNVT RPAAQPSFHQ AQKTHYPAQQ GEYQTHQPVY HKIQGDDWEP RPLRAASPFR SSVQGASSRE GSPARSSTPL HSPSPIRVHT VVDRPQQPMT HRET
Highest antigen sequence identity to orthologs:
- Mouse: 92%
- Rat: 91%
Target Information
BAG3 belongs to the BAG family of proteins that compete with Hip for binding to the Hsc70/Hsp70 ATPase domain, promoting substrate release. All BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ in their N-terminal regions. The BAG3 protein contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells, binding with high affinity and inhibiting chaperone activity in a Hip-repressible manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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