Thermo Fisher Scientific VNN1 Monoclonal Antibody (2B10)

Applications

Tested Dilution

Publications

ELISA (ELISA)

0.1 ng/mL

-

Immunoprecipitation (IP)

1-5 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

2B10

Immunogen

VNN1 (NP_004657, 298 a.a. approximately 397 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:VNN1,uniProtId:O95497-1,ncbiNodeId:9606,antigenRange:298-397,antigenLength:513,antigenImageFileName:H00008876-M05_VNN1_O95497-1_House_mouse.svg,antigenImageFileNamePDP:H00008876-M05_VNN1_O95497-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: KLLLSQLDSH PSHSAVVNWT SYASSIEALS SGNKEFKGTV FFDEFTFVKL TGVAGNYTVC QKDLCCHLSY KMSENIPNEV YALGAFDGLH TVEGRYYLQI

Target Information

Hematopoietic precursor cells migrate to the thymus, where they differentiate into mature T lymphocytes. GPI-anchored vanin-1 protein regulates the late adhesion steps of thymus homing of bone marrow precursor cells. Vanin-1 is ubiquitously expressed as a pantetheinase enzyme and catalyzes the hydrolysis of pantetheine for vitamin B5 recycling. The hydrolytic activity of vanin-1 generates the potent antioxidant cysteamine as a metabolite. As a membrane bound pantetheinase, vanin-1 provides the main source of cysteamine under normal physiological conditions. In mice, vanin-1 is expressed specifically in male Sertoli cells of the developing testis, where it aids in cell migration.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.