Thermo Fisher Scientific Torc1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.1–0.5 µg/mL

Product Specifications

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

Transcriptional coactivator for CREB1 that activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator in the SIK/TORC signaling pathway, being active when dephosphorylated and acting independently of CREB1 Ser-133 phosphorylation. Enhances the interaction of CREB1 with TAF4 and regulates expression of specific CREB-activated genes such as the steroidogenic gene StAR. Functions as a potent coactivator of PGC1α and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral–CA1 synapses. May be required for dendritic growth of developing cortical neurons. Together with SIK1, regulates the light-induced entrainment of the circadian clock by coactivating CREB-mediated transcription of PER1, important for photic entrainment.
[UniProt]

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.