Thermo Fisher Scientific ZC3HAV1 Polyclonal Antibody
인간 ZC3HAV1 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 및 ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS와 글리세롤 버퍼에 보관됩니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ZC3HAV1 (Product # RP-100590) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2649819 |
Product Specific Information
Immunogen sequence:
NGKSGTQDIQ PGPLFNNNAD GVATDITSTR SLNYKSTSSG HREISSPRIQ
DAGPASRDVQ ATGRIADDAD PRVALVNDSL SDVTSTTSSR VDDHDSEEIC LDHLHighest antigen sequence identity to the following orthologs:
- Mouse: 33%
- Rat: 23%
Target Information
The zinc finger antiviral protein (ZC3HAV1) is a CCCH-type zinc finger protein that induces innate immunity to retroviral infections by preventing accumulation of viral RNAs in the cytoplasm. It recruits the RNA processing exosome to degrade target RNAs, thereby inhibiting virus replication. ZC3HAV1 is localized in the cytoplasm at steady state but shuttles between the nucleus and cytoplasm in an XPO1-dependent manner. ZAP is a direct target gene of IRF3 action in cellular antiviral responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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