Thermo Fisher Scientific ZC3HAV1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human ZC3HAV1. Recombinant protein control fragment (Product #RP-100590). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ZC3HAV1,uniProtId:Q7Z2W4-1,ncbiNodeId:9606,antigenRange:414-517,antigenLength:902,antigenImageFileName:PA5-61598_ZC3HAV1_Q7Z2W4-1_Rabbit.svg,antigenImageFileNamePDP:PA5-61598_ZC3HAV1_Q7Z2W4-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2649819

Product Specific Information

Immunogen sequence: NGKSGTQDIQ PGPLFNNNAD GVATDITSTR SLNYKSTSSG HREISSPRIQ DAGPASRDVQ ATGRIADDAD PRVALVNDSL SDVTSTTSSR VDDHDSEEIC LDHL

Highest antigen sequence identity to the following orthologs: Mouse - 33%, Rat - 23%.

Target Information

The zinc finger antiviral protein (ZC3HAV1) is a CCCH type zinc finger protein that induces an innate immunity to infections by retrovirus by preventing the accumulation of viral RNAs in the cytoplasm and recruits the RNA processing exosome to degrade target RNAs, thereby inhibiting virus replication. ZC3HAV1 is localized in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner. ZAP is a direct target gene of IRF3 action in cellular antiviral responses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.