Thermo Fisher Scientific CSF1 Monoclonal Antibody (OTI2D6), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

M-CSF (Macrophage colony-stimulating factor, CSF-1) is a survival factor essential for the proliferation and development of monocytes, macrophages, and osteoclast progenitor cells.
It induces VEGF secretion by macrophages, mediating mobilization of endothelial progenitor cells and neovascularization.
M-CSF exists as several bioactive isoforms differing in potency and stability. The full-length protein is synthesized as a membrane-spanning protein that can be expressed on the cell surface or cleaved and modified in secretory vesicles.
M-CSF forms a disulfide-bonded homodimer processed into glycoprotein or proteoglycan isoforms.
Binding to its receptor c-Fms (CSF-1R/CD115) induces receptor dimerization, internalization, and degradation.
Functionally, M-CSF stimulates hematopoietic stem cell differentiation into monocyte-macrophage lineages.
Human M-CSF shows cross-species activity on mouse cells, but mouse CSF does not act on human cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.