Thermo Fisher Scientific TMP21 Polyclonal Antibody
TMP21 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, 인간 및 설치류 등 다양한 종에 반응합니다. 웨스턴 블롯에 적합하며, 항원 친화 크로마토그래피로 정제된 액상 형태입니다. -20°C에서 보관하며 연구용으로 사용됩니다.
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Thermo Fisher Scientific TMP21 Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1:1,000
Publications: - [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues of human TMP21 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10978570 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
TMP21 is a ubiquitously expressed protein involved in vesicular targeting and protein transport. It is also a component of the presenilin complex and modulates the γ-secretase but not the ε-secretase cleavage activity of the amyloid precursor protein. The presenilin complex includes APH1, nicastrin, and PEN2 in addition to presenilin-1. These proteins cleave the amyloid precursor protein at γ- and ε-sites, potentially leading to accumulation of the Abeta cleavage product associated with Alzheimer's disease.
Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21, indicating its role in regulating this complex. Suppression of TMP21 expression by siRNA increased γ-secretase activity and Abeta production, demonstrating that TMP21 can modulate γ-secretase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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