Thermo Fisher Scientific TNFR1 Polyclonal Antibody
Human TNFR1 단백질을 인식하는 Goat Polyclonal Antibody로 Western blot에 최적화됨. 0.5 mg/mL 농도의 액상형 제품이며, TBS 버퍼(pH 7.3, 0.5% BSA) 및 sodium azide 포함. -20°C 보관, 연구용 전용.
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Applications
Western Blot (WB)
- Tested Dilution: 0.3–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-SDHEIDRLELQNGR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933508 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
TNFR1 (Tumor necrosis factor receptor 1) belongs to the tumor necrosis factor superfamily and is one of the major TNF-alpha receptors. TNFR1 plays an important role in cytokine-mediated signaling, positive regulation of the NF-κB pathway, angiogenesis, and negative regulation of gene expression.
The extracellular domain of TNFR1 is released into the circulatory system as soluble TNFR1 (sTNFR1). In humans, the TNFR1 gene is located on chromosome 12.
Proteins such as BAG4/SODD, TRADD, and TRAF2 interact with TNFR1 and regulate its signal transduction. Germline mutations in the extracellular domain of TNFR1 are associated with autosomal dominant periodic fever syndrome, likely due to impaired receptor clearance.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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