Thermo Fisher Scientific IFNG Polyclonal Antibody, MaxPab
Human IFNG 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western Blot에 적합. 무보존제 PBS 용액 형태로 제공되며, Affinity Chromatography로 정제됨. IFN-γ 관련 면역 연구 및 세포 신호전달 분석에 활용 가능.
- 카탈로그번호
- H00003458-D01P
- 판매단위
- pk
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Applications
- Western Blot (WB): 1–5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | IFNG (AAH70256.1, 1 a.a. ~166 a.a) full-length human protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MKYTSYILAF QLCIVLGSLG CYCQDPYVKE AENLKKYFNA GHSDVADNGT LFLGILKNWK EESDRKIMQS QIVSFYFKLF KNFKDDQSIQ KSVETIKEDM NVKFFNSNKK KRDDFEKLTN YSVTDLNVQR KAIHELIQVM AELSPAAKTG KRKRSQMLFR GRRASQ
Target Information
IFN gamma (Interferon gamma, Type II interferon) is a macrophage activation factor and immune interferon produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, and cytokines.
It is a dimeric glycoprotein (~45 kDa) composed of two 146 amino acid subunits, exhibiting species-specific biological activity.
Human IFN gamma does not cross-react with mouse IFN gamma.
Functions include:
- Antiviral and tumor antiproliferative activity
- Induction of MHC class I and II expression
- Macrophage activation
- Enhanced immunoglobulin secretion by B lymphocytes
IFN gamma acts via the JAK-STAT signaling pathway and is regulated by various cytokines (upregulated by IL2, FGF basic, EGF; downregulated by vitamin D3 or DMN).
Mutations in the IFN gamma gene are associated with aplastic anemia.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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