Thermo Fisher Scientific Synphilin 1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human Synphilin 1 for Parkinson’s disease research. Validated for WB and IHC. Lyophilized form, unconjugated, stored at 4°C or -20°C. High specificity to Synphilin-1; reconstitute in sterile water before use.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | – |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | – |
| Miscellaneous PubMed (Misc) | – | View 2 publications |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the C-terminal region of human Synphilin 1 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
- The antigen shares 83% identity with mouse sequence.
- Specificity of this antibody: Synphilin-1.
Target Information
Parkinson’s disease is the second most common neurodegenerative disease after Alzheimer’s, affecting about 1% of people over 65 and 3% over 75. Mutations in SNCAIP (Synphilin-1) are linked to Parkinson’s disease. Synphilin-1 interacts with alpha-synuclein and contains several protein-protein interaction domains. Its amino acid sequence shows extensive homology between human and mouse, particularly in ankyrin-like motifs and coiled-coil domains. Synphilin-1 plays a key role in aggregate formation and cytotoxicity in Parkinson’s disease, and Dorfin may contribute through ubiquitylation of Synphilin-1. It is also involved in synaptic function, protein degradation, and molecular mechanisms leading to neurodegeneration.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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